Tretinoin vs Retinol

Tretinoin is prescription-only in many countries, while retinol is sold over the counter. Both are forms of vitamin A, but they behave very differently.

Strength & speed

• Tretinoin: already active retinoic acid – no conversion needed, very potent.
• Retinol: weaker, needs conversion inside the skin, usually slower but easier to tolerate.

This is why tretinoin is often used in dermatology for acne and photo-ageing, while retinol is used in cosmetic skincare for gradual, long-term improvement.

Who is tretinoin for?

Tretinoin is a medical treatment, not just a “stronger retinol”. It’s typically used for:

• Significant photo-ageing (deep lines, sun damage, texture).
• Stubborn acne that hasn’t responded to milder options.
• Melasma or complex pigmentation issues – under medical supervision.

Because it is so potent, tretinoin should be started and adjusted with the help of a doctor or dermatologist who can guide strength, frequency and support products.

When retinol is the better choice

• You’re just starting with vitamin A.
• You prefer slow, steady progress over aggressive peeling.
• You don’t have access to a dermatologist or prescription.
• Your main goals are mild texture, glow and early fine lines.

Many people never need tretinoin at all. A well-formulated retinol or retinal product used consistently can deliver impressive long-term results with fewer side effects and less downtime.

A quick way to think about it

If you’re still learning how your skin reacts to actives, or your barrier is easily irritated, start with a beginner-friendly retinol. If, after a long period of consistent use, you still feel you need something stronger, that’s the time to discuss tretinoin with a professional.

Nothing on this page is medical advice. Always talk to your own doctor or dermatologist before starting prescription treatments or if you have ongoing skin concerns.